As the sole head of The Spectator, Nate (Chace Crawford) is making his own decisions and is ready to go up against Gossip Girl.
As word spreads that Serena (Blake Lively) is missing, the gang bands together to find her and are shocked by what they find.
Watch a sneak peek below:
Kelly Rutherford, Matthew Settle and Kaylee DeFer also star.
Barry Watson (7TH HEAVEN), Andrea Gabriel (LOST), Robert John Burke and Sofia Black-D'Elia (SKINS) guest star.
Mark Piznarski directed the episode written by Stephanie Savage and Josh Schwartz.
GOSSIP GIRL airs Mondays at 9 p.m. ET/PT on The CW.