GREY'S ANATOMY Season 10 Premiere Preview

Photo Credit: ABC

GREY'S ANATOMY returns for its tenth season with a two-hour event on Thursday, September 26 at 9 p.m. ET/PT on ABC.

In the first hour, "Seal Our Fate" (9-10 p.m.), the Grey Sloan Memorial Hospital doctors are faced with the devastation left by the storm. A giant mudslide in Seattle injures a group of first responders and citizens, causing the already shorthanded ER to spring into action. Meanwhile, Meredith is faced with a tough decision that will affect the life of a loved one, Callie is rocked by the reality of Arizona's infidelity, and Richard's life is in extreme danger.

In the second hour, "I Want You With Me" (10-11 p.m.), the fight continues to save those affected by the storm, Callie makes a bold decision regarding her relationship, and the doctors come together upon receiving devastating news.



GREY'S ANATOMY stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Jesse Williams as Jackson Avery, Sarah Drew as April Kepner, Camilla Luddington as Jo Wilson, Gaius Charles as Shane Ross, Jerrika Hinton as Stephanie Edwards and Tessa Ferrer as Leah Murphy.

Guest cast for "Seal Our Fate" includes Veronica Cartwright as Lydia Ashford, Tina Majorino as Dr. Heather Brooks, Heather Hemmens as Sasha and Bobby Campo as Brian. "Seal Our Fate" was written by Joan Rater and directed by Rob Corn.

"I Want You With Me" was written by Debora Cahn and directed by Chandra Wilson.