'Grey's Anatomy' Season 15 Premieres September 27

The two-hour season premiere of Grey's Anatomy airs Thursday, September 27 from 8 to 10 p.m. ET/PT on ABC.

During the first hour, the doctors at Grey Sloan Memorial vie for a new position. Meredith is seemingly distracted and struggles to stay focused, and Maggie finds herself the keeper of a big secret while Amelia and Owen try to figure out their relationship. Meanwhile, Jo and Alex’s honeymoon doesn’t go exactly as planned.

Guest starring is Debbie Allen as Catherine Avery, Stefania Spampinato as Carina DeLuca, Jake Borelli as Levi Schmitt, Alex Blue Davis as Casey Parker and Rushi Kota as Vik Roy.

In the second hour, new doctors continue to shake up the hospital in typical Grey Sloan manner. Meredith bonds with a patient while Jackson struggles with the meaning behind recent experiences; and after making a life-changing decision, Jo forms an unexpected alliance.

Guest starring is Chris Carmack as Link, Jake Borelli as Levi Schmitt, Alex Blue Davis as Casey Parker, Sophia Ali Taylor as Dahlia Qadri and Jaicy Elliot as Taryn Helm.

Watch a Season 15 teaser video below.

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