Actress Liz Dawn, who plays Vera Duckworth in Coronation Street, is to leave the soap due to ill health.
Ms Dawn, who has played her character for the past 34 years, will leave the ITV show before Christmas.
The 68-year-old actress has the lung disease emphysema and, according to the News of the World, has told Granada she is too sick to continue.
She said she wanted to "thank everyone" for "the best time of my life" during her years in the popular soap.
Producers would not say how Ms Dawn is to be written out of her £200,000 role, but said she would continue to make guest appearances on the show.
Her character's husband Jack, played by Bill Tarmey, will remain in the soap.
She said: "It's been an amazing 34 years. I'd like to thank everyone for what has been the best time of my life."
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