"Very excited!!" executive producer Frank Valentini wrote on Twitter after announcing the news.
Head writer Ron Carlivati chimed in with the tweet: "Fire up the spaceship! #GH #HollyIsBack @EmmaSamms1"
Added Samms: "Hooray! I don't have to keep the secret anymore.."
Holly first appeared on General Hospital in 1982, staying for a 3-year run. She returned in 1992-1993, and then again in 2006, 2009, 2012 and 2013.
She joins Genie Francis' Laura as characters from Luke's past coming back to the show as part as Anthony Geary's goodbye story.