In "The End is the Beginning is the End," Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark Sloane's old patients.
Meanwhile, Derek begins recovery on his hand.
Watch a sneak peek below:
GREY'S ANATOMY stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Jesse Williams as Jackson Avery and Sarah Drew as April Kepner.
"The End is the Beginning is the End" was written by Joan Rater and directed by Cherie Nowlan.
Fans will be able to submit questions and receive real-time responses from actors Camilla Luddington (Dr. Josephine "Jo" Wilson) and Gaius Charles (Dr. Shane Ross), who will be up on Twitter at @camilluddington and @gaiuscharles, respectively, during the West Coast broadcast of the show from 9:00-10:02 p.m. PT.