The news was broken by the Opie and Anthony Show, the same pogram which first revealed details of his illness.
The show's official Twitter feed said: "Yes it's true that our pal Patrice O'Neal has passed away. The funniest and best thinker I've ever known. Period."
O’Neal was a comic since 1992, and spent some time in the late '90s honing his act on the UK circuit. In February this year, he had his first Comedy Central hour-long special, ELEPHANT IN THE ROOM.
O'Neal spoke to Atlantic City Weekly last year about his time on the WWE creative team. Below is what he had to say:
It was actually a dream situation, but I think if I had kept doing it, it wouldn’t have been a dream. When I stopped doing it, it was perfect. It was just to be able to say I did it and it was like, ‘Wow, I actually got the job!’ You know, you had to audition to get it so I actually wrote a scenario where they wanted me to write a finish to an existing beef and conclude it in a Pay-per-View match. I think I was doing the Undertaker and Triple H and I had to escalate it for three weeks and then end it with a Pay-per-View. At the time I was really into wrestling so that was easy to do and my writing sample got the job. It was fun; I flew around on a WWE jet, [got to] roll with some of the big-time wrestlers ... and directed a couple of vignettes. [WWE chairman and CEO] Vince McMahon was one of the few people I’ve ever seen that I was in complete awe of his presence, you know? He was the man, he was the boss. I learned a lot of things in like three days looking at Vince McMahon and how he operates; it was a hell of a thing. So when that ended it was almost like it should've ended cause it was a good experience and I didn’t have to see anything I shouldn’t see and didn’t have to deal with anything I shouldn’t have dealt with. It was just short and sweet.